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Dr. Juan García-Huidobro

Cargo: 
Dpto. de Biología.
E-mail: 
juan.garcia-huidobro@usach.cl
Biografía: 

Postdoctorado, Department of Pharmacology, New York University, (NYU), USA (1979-1980).

Doctor en Farmacología, Universidad de California, San Francisco, UCSF, 1978

Licenciado en Ciencias Biológicas, Facultad de Medicina, Pontificia Universidad Católica de Chile (1971)

Lineas de Investigación: 

Biomedicina

Proyectos: 
  • Enhanced endothelial signaling by dietary polyphenols and potassium supplements in controls and STZ-diabetic rats. FONDECYT 1170-842. (2017-2019). PI
  • ATP and D-serine interplay in breathing regulation; key players in health and disease FONDECYT 1211359. (2021-2025). Co-investigator
  • Anthocyanins and phytoestrogens as GPER ligands DICYT 022143-GHT. (2021-2023). PI
Últimas Publicaciones: 

13.- Morgan Bas, Felipe Hernández and JP Huidobro-Toro (2020). Architecture of life molecules, a contribution of L. Pasteurto molecular pharmacology; opportunities for adrenergic pharmacology developments. Comptes Rendus Chemie 23, 3-16.

12.- Robles-Planella, C. Barrera-Avalos, C. Rojo, L., Spencer, E., Cortez-San Martìn, M., Pavez,J……  Huidobro-Toro, JP, Fernández, R., Acuña-Castillo, C. (2020). Chitosan-based delivery of avian Reovirus Fusogenuc protein p10 gene. BioMed Res Int., doi.org10.1155/2020/8680692

11.- Robles-Planella, C. Sánchez-Guerrero, G., Barrera-Avalos, C., Rojo, L, Pavez, J. Huidobro-Toro, Acuña-Castillo, C. (2020). Chitosan-based nanoparticles for intracellular delivery of ISAV fusion protein cDNA. BioMed Res Int doi.org10.1155/2020/8680692

10.- Peralta, FA., and Huidobro-Toro, JP (2020). New Insights of the Zn(II)-induced P2X4 positive allosteric modulation: role of head receptor domain SS2/SS3, E 160 and D170. Int. J. Mol. Sciences, 21:6940-6960

9.- Peralta, F.A. Huidobro-Toro, and Mera, R. (2021).Hybrid QM/MM simulations confirm Zn(II) coordination sphere includes four cysteines from P2X head receptor domain. Int. J. Mol. Sciences, 22, 7288-7300.

8.- Calfío, C., Donoso, F., Huidobro-Toro, JP (2021). Anthocyanins activate membrane estrogen receptor with nanomolar potency to elicit a nongenomic vascular response via NO production J. Am Heart Assoc  Doi.101161/JAHA/119020498

7.- Barrera-Avalos, C., Briceño, P, Valdes, D., Imarai, M Leiva-Salcedo, E., Huidobro-Toro, JP. Acuña-Castillo, C. (2021). P2X7R is essential for cross-dressing of bone marrow-derived dendritic cells iScience  24, 103520-103538

6.- Donoso, F., Sagredo, P., Garcìa-Huidobro, JP.  (2021). D. Julius y A Patapoutian, Premios Nobel de Medicina 2021 descubren nuevos canales iónicos que detectan temperaturas y estímulos mecànicos Rev. Méd Chile 150-88-92, 2021

5.- Mascayano, C., Muñoz-Osses, M., Navarrete, E., Torres, P., Morales, P., Huidobro-Toro, JP.  (2023) Natural pentacyclic tripertenoid as allosteric modulators of h5-LOX with potential anti-inflammatory activity. J.BioMed Struct and Dyn, doi.org/10.1080/073911102.2023. 2276875

4.- Donoso, MV., Hernández, F., Barra, R., Huidobro-Toro, JP. (2023). Nanomolar clodronate induces adnosine accumulation in the perfused rat mesenteric bed and mesentery- derived endothelial cells Frontiers in Pharmacology. Doi10.3389/fphar.2022.1031223

3.- Donoso, MV., Catalán-Salas, V., Pulgar-Sepúlveda, R., 2024Eugenín, J Huidobro-Toro, JP . (2024) Physiology, Pathophysiology and clinical relevance of D-Amino acids dynamics: from neurochemistry to Pharmacotherapy. The Chemical Record. Doi10.1002/tcr2024000013

2.- Catalán-Salas, V., Sagredo, P., Melgarejo, W., Donoso, M.V., Cárdenas, J.C., Zakarian, A., Valdés, D., Acuña-Castillo, C., Huidobro-Toro, JP. (2024). 17b-estradiol and phytoestrogens elicit NO production and vasodilatation through Pi3K, PKA and EGF receptors pathways , evidencing functional selctivty Eur. J. Pharmacol. Doi  10.1016/jeppharm.2024.176636

1.- Leiva-Salcedo, E., Riquelme, D., Huidobro-Toro, JP Coddou, C., (2024). Copper increases the cooperative gating of rat P2X4 receptors. Pharmaceuticals Doi 10.3390 /pharmaceu.