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Dr. Leonel Rojo
Dr. Leonel Rojo es licenciado en Farmacia y Químico Farmacéutico de la Universidad de Concepción, Doctor en Farmacología por la Universidad de Chile. Realizó, Postdoctorado en la Universidad de Rutgers en Estados Unidos. Además es egresado de Licensing Academy en University of California, Davis. Durante su carrera ha sido académico visitante Kwantlen Polytechnic University, Vancouver, Canadá, Albert Einstein College of Medicine, NY, USA, Brain-Mind Project, Inc., USA, Encephalogistics, Inc, USA y National Institute of Engineering and Technology (INETI) en Lisboa, Portugal. El Dr. Rojo actualmente es Profesor de la Universidad de Santiago de Chile. Co-fundador y miembro del Instituto de Etnofarmacología en la Región de Tarapacá y consultor independiente para empresas de área biomédica, tecnologías médicas y farmacia. Miembro Comité Directivo FONDEF-Proyecto N° ID19I10301 (2020-2023)
Tecnologías diagnóstico en Enfermedades Neurodegenerativas, Nuevas Moléculas Naturales en Diabetes y Resistencia a Insulina
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2020-2023 FONDEF N° ID19I10301 “Validación técnica y comercial de la Tecnología Alz-tau®. Comité Directivo (2020-2023)
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2015-2017, Evaluation of Anthocyanins from Maqui Berry in the prevention of Clozapine-Induced Hepatic Lipid Accumulation, Activation of SREBP1c Target Genes and Obesity, FONDECYT INIC. N° 11140915
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2014-2017 Radiopharmaceuticals to visualize neurofibrillary tangles in vivo CORFO-14IEAT-28666, Chile, Investigador
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2014-2015 Generación de Capacidades de Transferencia Tecnológica en Corporación de Desarrollo de la Universidad Arturo Prat" 14CHTT-34739, CORFO Chile
1. Barrera-Avalos C, Díaz X, Madrid B, Michelson SA, Robles-Planells C, Sánchez-Guerrero G, Ahumada V, Mella-Torres A, Rojo LE, Imarai M, Milla LA, Leiva-Salcedo E, Murgas P, Fernández R, Escobar A, Acuña-Castillo C. In Vivo Antitumor Effect against Murine Cells of CT26 Colon Cancer and EL4 Lymphoma by Autologous Whole Tumor Dead Cells. Biomed Res Int. 2021 Feb 3;2021:6626851. doi: 10.1155/2021/6626851. PMID: 33623783; PMCID: PMC7875630.
IF: 2.583 Q2
2. Barrera-Avalos C, Mena J, López X, Cappelli C, Neira T, Imarai M, Fernández R, Robles-Planells C, Rojo LE, Milla LA, Leiva-Salcedo E, Escobar A, Acuña-Castillo C. Adenosine triphosphate, polymyxin B and B16 cell-derived immunization induce anticancer response. Immunotherapy. 2021 Mar;13(4):309-326. doi: 10.2217/imt-2020-0209. Epub 2021 Jan 5. PMID: 33397152.
IF: 2.716 .Q2
3. Andrade V, Cortés N, Pastor G, Gonzalez A, Ramos-Escobar N, Pastene E, Rojo LE*, Maccioni RB. (2020), N-Acetyl Cysteine and Catechin-Derived Polyphenols: A Path Toward Multi-Target Compounds Against Alzheimer's Disease. J Alzheimers Dis. 2020;75(4):1219-1227. doi: 10.3233/JAD-200067,
IF: 3.909. Q1
4. Díaz-Castro, F., Monsalves-Álvarez, M., Rojo, L. E., Del Campo, A., & Troncoso, R. (2020). Mifepristone for Treatment of Metabolic Syndrome: Beyond Cushing's Syndrome. Frontiers in pharmacology, 11, 429. https://doi.org/10.3389/fphar.2020.00429.
IF 4.4. Q1
5. Robles-Planells C, Barrera-Avalos C, Rojo LE, Spencer E, Cortez-San Martin M, Matiacevich S, Pavez J, Milla LA, Navarro FD, Martínez BA, Bravo FJ, Mella A, Huidobro-Toro JP, Fernandez R, Escobar A, Acuña-Castillo C (2020), BioMed Research International "Chitosan-Based Delivery of Avian Reovirus Fusogenic Protein p10 Gene: In Vitro and In Vivo Studies towards a New Vaccine against Melanoma, Article ID 4045760, 11 pages, https://doi.org/10.1155/2020/4045760,
IF: 2.27. Q1
6. Robles-Planells, C., Sánchez-Guerrero, G., Barrera-Avalos, C., Matiacevich, S., Rojo, L. E., Pavez, J., Salas-Huenuleo, E., Kogan, M. J., Escobar, A., Milla, L. A., Fernandez, R., Imarai, M., Spencer, E., Huidobro-Toro, J. P., & Acuña-Castillo, C. (2020). Chitosan-Based Nanoparticles for Intracellular Delivery of ISAV Fusion Protein cDNA into Melanoma Cells: A Path to Develop Oncolytic Anticancer Therapies. Mediators of inflammation, 2020, 8680692. https://doi.org/10.1155/2020/8680692,
IF: 3.758. Q1
7. Calfio C, Gonzalez A, Singh SK, Rojo LE, Maccioni RB. The Emerging Role of Nutraceuticals and Phytochemicals in the Prevention and Treatment of Alzheimer's Disease. (2020), J Alzheimers Dis. 2020;77(1):33-51. doi: 10.3233/JAD-200443. PMID: 32651325.
IF: 3.909. Q1
8. Robles-Planells, C., Michelson, S. A., Mena, J., Escrig, D., Rojas, J. L., Sanchez-Guerrero, G., Hernández, R., Barrera-Avalos, C., Rojo, L. E., Sauma, D., Kalergis, A. M., Imarai, M., Fernández, R., Robles, C. A., Leiva-Salcedo, E., Santander, R., Escobar, A., & Acuña-Castillo, C. (2019). Frontiers in pharmacology, Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma., 10, 1201. https://doi.org/10.3389/fphar.2019.01201
IF: 4.4. Q1
9. Del Campo A, Bustos C, Mascayano C, Acuña-Castillo C, Troncoso R and Rojo LE* (2018). Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance. Frontiers in Endocrinology, Frontiers Media SA, 9:144. doi: 10.3389/fendo.2018.00144,
IF: 3.675. Q1
10. Morales J, Barrera-Avalos C, Castro C, Castillo S, Barrientos C, Robles-Planells c, Lopez X, Torres E, Montoya M, Cortez-San Martín M, Riquelme D, Escobar A, Fernandez R, Imarai M, Sauma D, Rojo LE, Leiva-Salcedo E, Acuña-Castillo C (2017). Dead Tumor Cells expressing ISAV fusogenic protein favor antigen cross-priming in vitro. Frontiers in Immunology, Frontiers Media SA, 2017 Oct 9;8:1170. doi: 10.3389/fimmu.2017.01170., eCollection 2017.
IF: 6.429. Q1
11. Castillo RI, Rojo LE*, Henriquez-Henriquez M, Silva H, Maturana A, Villar MJ, Fuentes M, Gaspar PA* (2016). From Molecules to the Clinic: Linking Schizophrenia and Metabolic Syndrome through Sphingolipids Metabolism. Frontiers in Neuroscience, Frontiers Media SA, 10:488. eCollection 2016,
IF: 4.555. Q1
12. Rojo LE*, Gaspar PA, Silva H, Risco L, Arena P, Cubillos-Robles K, Jara B, (2015). Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology. Pharmacological Research, Academic Press LTD- Elsevier Science LTD, 101:74-85,
IF: 4.480. Q1
13. Graf, B. L., Rojas-Silva, P., Rojo, L. E., Delatorre-Herrera, J., Baldeón, M. E., and Raskin, I (2015). Innovations in Health Value and Functional Food Development of Quinoa (Chenopodium quinoa Willd.). Comprehensive Reviews in Food Science and Food Safety, Wiley, 14(4):431-445,
IF: 5.974. Q1
14. Graf BL, Rojo L.E., J. Delatorre-Herrera, A. Poulev, C. Del Pilar Calfio, and I. Raskin (2015). Phytoecdysteroids and flavonoid glycosides among Chilean and commercial sources of Chenopodium quinoa: variation and correlation to physicochemical characteristics. Journal of the Science of Food and Agriculture, Wiley, 96(2):633-43,
IF: 2.463. Q1