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Dr. Luis Constandil

Cargo: 
Dpto. Biología. Laboratorio de Neurobiología
E-mail: 
luis.constandil@usach.cl

Up today there exist a number of drugs able to inhibit the acute pain. Nevertheless, these drugs are not capable of inhibiting completely chronic pain types. Even though there exist abundant knowledge about the pain pathways to the cerebral cortex,   neither the neurotransmitters participating in these pathways nor the regulatory mechanisms involved is known. Furthermore, quite a few is also known about the mechanisms involved in the codification and discrimination of tactile and painful sensations. Additionally, is also poorly understood the plastic changes involved in the response of the organism to chronic pain. This kind of interrogate has leaded our Lab to the study chronic neuropathic and arthritic chronic pain in animal models. A typical chronic pain is produced during a migraine episode. Once initiated, this pain is maintained in time due to peripheral and central sensitization. Even though the physiopathology of migraine has been deeply studied, their genesis and the mechanisms of central sensitization are still unknown. Into this topic, we development an system for long lasting drug delivery based in polymeric nanoparticle.

Biografía: 

Doctor en Ciencias Biológicas, mención Ciencias Fisiológicas. Pontificia Universidad Católica de Chile. 1997 Santiago, Chile.

Licenciado en Ciencias Biológicas. Pontificia Universidad Católica de Chile. Santiago, Chile

Lineas de Investigación: 

Biomedicina. Fisiopatología y neuroplasticidad en el dolor crónico

Proyectos: 
  • Desarrollo de una formulación nano-biotecnológica en base a fungicidas orgánicos para la prevención y tratamiento de enfermedades de la madera en frutales. FONDEF-IDEA ID24I10382. (2024-2026). Director
  • Role of DNIC in a rat model of fibromyalgia induced by neonatal stress: neurotransmitters and glial modulation in the SRD and epigenetic influences. FONDECYT 1231042. (2023-2027). Responsable
  • Role of DNIC in a rat model of fibromyalgia induced by neonatal stress: neurotransmitters and glial modulation in the SRD and epigenetic influences. Dicyt 5392202CC-AC. (2022) Responsible.
  • Preclinical study on the participation of pannexin 1 (Panx1) in spinal cord circuitry and its role in the mechanisms of chronic pain. FONDECYT 1181622. (2018-2021). Responsible
Últimas Publicaciones: 

16.- Katherine Zepeda-Morales, David Bravo, Jonathan Aránguiz-Barrera, Estibaliz Ampuero, Georgina M. Renard, Teresa Pelissier, Alejandro Hernández, Jeffri S. Retamal, Luis Constandil (2024). NMDA receptor activation is downstream coupled to pannexin 1 opening by Src kinase in dorsal horn neurons: an essential link for mechanical hyperalgesia in nerve-injured rats Pain

15.- Lobos, N., Lux, S., Zepeda, R. J., Pelissier, T., Marcos, J. L., Bustos-Quevedo, G., Hernández, A., & Constandil, L. (2023) .Rosuvastatin Synergistically Enhances the Antinociceptive Efficacy of Duloxetine in Paclitaxel-Induced Neuropathic Pain in Mice. International journal of molecular sciences, 24(9),

14.- Cayupe, B., Troncoso, B., Morgan, C., Sáez-Briones, P., Sotomayor-Zárate, R., Constandil, L., Hernández, A., Morselli, E., & Barra, R. (2022). The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition. International journal of molecular sciences, 23(19), 11965

13.- Morgan, C., Sáez-Briones, P., Barra, R., Reyes, A., Zepeda-Morales, K., Constandil, L., Ríos, M., Ramírez, P., Burgos, H., & Hernández, A. (2022). Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity. International journal of molecular sciences, 23(17), 10089

12.- Bravo, D., Zepeda-Morales, K., Maturana, C. J., Retamal, J. S., Hernández, A., Pelissier, T., Barra, R., Sáez-Briones, P., Burgos, H., & Constandil, L. (2022) NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats. International journal of molecular sciences, 23(12),

11.- Casadei, M., Fiore, E., Rubione, J., Domínguez, L. M., Coronel, M. F., Leiguarda, C., García, M., Mazzolini, G., Villar, M. J., Montaner, A., Constandil, L., Romero-Sandoval, E. A., & Brumovsky, P. R.  (2022). IMT504 blocks allodynia in rats with spared nerve injury by promoting the migration of mesenchymal stem cells and by favoring an anti-inflammatory milieu at the injured nerve Pain 2022 Jun 1;163(6):1114-1129

10.- Cayupe, B., Morgan, C., Puentes, G., Valladares, L., Burgos, H., Castillo, A., Hernández, A., Constandil, L., Ríos, M., Sáez-Briones, P., & Barra, R.  (2021). Hypertension in Prenatally Undernourished Young-Adult Rats Is Maintained by Tonic Reciprocal Paraventricular-Coerulear Excitatory Interactions Molecules. 2021 Jun 11;26(12):3568

9.- Leiguarda, C., Villarreal, A., Potilinski, C., Pelissier, T., Coronel, M. F., Bayo, J., Ramos, A. J., Montaner, A., Villar, M. J., Constandil, L., & Brumovsky, P. R.  (2021).  Intrathecal Administration of an Anti-nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization J Neuroimmune Pharmacol. 2021 Dec;16(4):818-834.

8.- Cerro, D., Bustos, G., Villegas, C., Buendia, N., Truffa, G., Godoy, M. P., Rodríguez, F., Rojas, A., Galotto, M. J., Constandil, L., Yáñez-S, M., Romero, J., & Torres, A. (2021). Effect of supercritical incorporation of cinnamaldehyde on physical-chemical properties, disintegration and toxicity studies of PLA/lignin nanocomposites Int J Biol Macromol. 2021 Jan 15; 167:255-266.

7.- Leiguarda, C., Potilinski, C., Rubione, J., Tate, P., Villar, M. J., Montaner, A., Bisagno, V., Constandil, L. (2021). IMT504 Provides Analgesia by Modulating Cell Infiltrate and Inflammatory Milieu in a Chronic Pain Model J Neuroimmune Pharmacol. 2021 Sep;16(3):651-666.

6.- Valeria González, Teresa Pelissier, Victoria Cazanga1 Alejandro Hernández and Luis Constandil (2021) Magnesium Salt, a Simple Strategy to Improve Methadone Analgesia in Chronic Pain: An Isobolographic Preclinical Study in Neuropathic Mice Front. Pharmacol., 08 May 2020, Vol11, Article 566, 1-10

5.- Paulina D. Ramírez-García, Jeffri S. Retamal, Priyank Shenoy, Wendy Imlach, Matthew Sykes, Nghia Truong, Luis Constandil, Teresa Pelissier, ……, Nicholas A. Veldhuis, Thomas P. Davis, Nigel W. Bunnett. (2019) A pH-Responsive Nanoparticle Targets the Neurokinin 1 Receptor in Endosomes to Prevent Chronic Pain Nature Nanotechnology, 2019 Dec;14(12):1150-1159.

4.- Burgos H, Hernández A, Constandil L, Ríos M, Flores O, Puentes G, Hernández K, Morgan C, Valladares L, Castillo A, Cofre C, Milla LA, Sáez-Briones P, Barra R. (2019). “Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats” Behav Brain Res. 2019 May 2; 363:182-190.

3.- Lux S, Lobos N, Lespay-Rebolledo C, Salas-Huenuleo E, Kogan MJ, Flores C, Pinto M, Hernandez A, Pelissier T, Constandil L. (2019) The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat J Pharm Pharmacol. 2019 May;71(5):816-825.

2.- Carvallo C, Contreras D, Ugarte G, Delgado R, Pancetti F, Rozas C, Piña R, Constandil L, Zeise ML, Morales B (2018). Single and Repeated Administration of Methylphenidate Modulates Synaptic Plasticity in Opposite Directions via Insertion of AMPA Receptors in Rat Hippocampal Neurons Front Pharmacol. 2018 Dec 19; 9:1485.

1.- Jeffri Retamal, Andrea Reyes, Paulina Ramirez, David Bravo, Alejandro Hernandez, Teresa Pelissier, Luis Villanueva and Luis Constandil. (2018). Burst-Like Subcutaneous Electrical Stimulation Induces BDNF-Mediated, Cyclotraxin B-Sensitive Central Sensitization in Rat Spinal Cord Front Pharmacol. 2018 Oct 10; 9:1143.