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Dra. Alejandra Moenne
La Dra Moenne nació en Concepción, Chile, y realizó su enseñanza primaria y secundaria en la Alianza Francesa de Concepción, Liceo Charles de Gaulle. Luego continuó con sus estudios universitarios en la Universidad de Concepción y cursó la carrera de Bioquímica (1979-1984) siendo galardonada con el Premio “Universidad de Concepción” al mejor graduado del año 1984. Realizó su Tesis Doctoral en el Comissariat de L´Enérgie Atomique de Saclay, en Paris, Francia, bajo la supervisión del Dr. André Sentenac (1984-1989). Hizó un postdoctorado en la Universidad Católica de Chile (1990-1995), bajo la supervisión del Dr. Xavier Jordana.
Posteriormente fue contratada en 1995 en la Universidad de Santiago de Chile como profesor asistente, y luego promovida a Profesor Asociado en 2002 y a Profesor Titular en 2012.
Durante estos últimos 20 años, ha trabajado en dos líneas de investigación:
- Mecanismos fisiológicos, celulares y moleculares de la tolerancia y acumulación de cobre y cadmio en el alga marina Ulva compressa (Cholophyta)
- Mecanismos fisiológicos, celulares y moleculares de la estimulación del crecimiento y la defensa contra patógenos inducida por oligo-carragenanos de algas marinas en plantas terrestres, principalmente oligo-carrageano kappa.
La ejecución de estas dos líneas de investigación ha dado origen a más de 30 publicaciones en revistas tales como Plant Physiology, Plant Cell and Environment, Frontiers in Plant Science, BMC Plant Biology, Algal Research, Aquatic Toxicology, entre otras. Además, ha participado en la formación de casi 20 alumnos de pregrado y 5 de Doctorado.
- Copper-induced activation of Transient Receptor Potential (TRP) and Voltage-Dependent Calcium Channels (VDCC) and the regulation by secreted redox compounds, NO, calmodulins and CDPKs and in the marine alga Ulva compressa. Fondecyt Regular 1130118. (2013-2019). IR
- Copper-induced expression of metallothioneins and synthesis of phytochelatins are involved in copper accumulation and tolerance in the marine macroalga Ulva compressa (Chlorophyta). Fondecyt Regular1160013 (2016-2019). IR
- Unraveling the mecagnismsm involved in copper, cadmium and zinc accumulation if the marine laga Ulva compressa (Chlrophyta). Fondecyt Regular 1230087. (2023-2026). IR
22.- González A, Sáez CA, Morales B, Moenne A. (2018). Copper-induced activation of TRP channels promotes extracellular calcium entry and activation of CaMK, PKA, PKC, PKG and CBLPK leading to increased expression of antioxidant enzymes in Ectocarpus siliculosus . Plant Physiology and Biochemistry
21.- González A, Sáez CA, Moenne A. (2018). Copper-induced activation of TRPs and VDCCs triggers a calcium signature response regulating gene expression in Ectocarpus siliculosus. PeerJ
20.- Rodríguez F, Laporte D, González A, Méndez K, Castro-Nallar E, Meneses C, Huidobro-Toro JP, Moenne A . (2018). Copper-induced increased expression of genes involved in photosynthesis, carotenoid synthesis and C assimilation in the marine alga Ulva compressa. BMC Genomics
19.- Navarrete A, González A, Gómez M, Contreras RA, Díaz P, Lobos G, Brown MT, Sáez CA, Moenne A. (2019). Coper excess detoxification is mediated by a coordinated and complementary induction of glutathione, phytochelatins and metallothioneins in the green seaweed Ulva compressa. Plant Physiology and Biochemistry
18.- Saucedo S, González A, Gómez M, Contreras RA, Laporte D, Sáez Ca, Zúñiga G, Moenne A. (2019). Oligo-carrageenan kappa increases glucose, trehalose and TOR-P and subsequently stimulates the expression of genes involved in photosynthesis, and basal and secondary metabolisms in Eucalyptus globulus. BMC Plant Biology
17.- Celis-Pla P, Rodríguez Rojas, Méndes L, Moenne F, Muñoz PT, Lobos MG, Díaz P, Sánchez-Lizaso JL, Brown MT, Moenne A, Sáez CA. (2019). MAPK pathway under chronic copper excess in green macroalgae (Chlorophyta): Influence in metal exclusion/extrusion mechanisms and photosynthesis International Journal of Molecular Sciences.
16.- Rodríguez-Rojas F, Celis-Pla P, Méndez L, Moenne F, Muñoz PT, Lobos MG, Díaz P, Sánchez-Lizaso JL, Brown MT, Moenne A, Sáez CA. (2019). MAPK pathway under chronic copper excess in green macroalgae (Chlorophyta): involvement in the regulation of detoxification mechanisms International Journal of Molecular Sciences
15.- Zúñiga A, Laporte D, González A, Gómez M, Sáez CA, Moenne A. (2020). Isolation and characterization of copper- and zinc-binding metallothioneins from the marine alga Ulva compressa (Chlorophyta). International Journal of Molecular Sciences
14.- Laporte D, Rodríguez F, González a, Zúñiga A, Castro-Nallar E, Sáez CA, Moenne A. (2020). Copper-induced concomitant increases in photosynthesis, respiration, and C, N and S assimilation revealed by transcriptomic analyses in Ulva compressa (Chlorophyta). BMC Plant Biology.
13.- Laporte D, González A, Moenne A. (2020). Copper-induced activation of MAPKs, CDPKs and CaMKs triggers activayion of hexokinase and inhibition of pyruvate kinase leading to increased synthesis od ASC, GSH and NADPH in Ulva compressa. Frontiers in Plant Science
12.- Moenne A, Gómez M, Laporte D, Espinoza D, Sáez CA, González A. (2020). Mechanisms of copper tolerance, accumulation and detoxification in the marine macroalga Ulva compressa (Chlorophyta): 20 years of research. Plants
11.- González A, Espinoza D, Vidal C, Moenne A. (2020). Benzopyrene induced oxidative stress and increased expression and activities of antioxidant enzymes, and CYP450 and GST metabolizing enzymes in Ulva lactuca (Chlorophyta). Planta
10.- Espinoza D, González a, Pizarro J, Segura R, Laporte D, Rodríguez-Rojas F, Sáez CA, Moenne A . (2021). Ulva compressa from copper-polluted sites exhibits intracellular copper accumulation, increased expression of mellathioneins and copper-containing nanoparticles in the chloroplasts. International Journal of Molecular Sciences
9.- González A, Vidal C, Espinoza D, Moenne A. (2021). Anthracene induced oxidative stress and activation of antioxidant and detoxification enzymes in Ulva lactuca (Chlorophyta). Scientific Reports.
8.- Moenne A, González A. (2021). Chitosan-, alginate-, carrageenan-derived oligosaccharides stimulate defense against biotic and abiotic stresses, and growth in plants: A historical perspective. Carbohydrate Research
7.- González A, Laporte D, Moenne A (2021). Cadmium accumulation involves synthesis of glutathione and phytochelatins, and activation of CDPK, CaMK, CBLPK and MAPK signaling pathways in Ulva compressa. Frontiers in Plant Science
6.- Osorio H, Tapia-Reyes P, Espinoza D, Laporte D, González A, Castro-Nallar E, Moenne A. (2022). The genoma of the marine alga Ulva compressa (Chlorophyta) reveal protein-coding genes with sumularity to plants and green microalgae, but also to animal, bacterial and fungal genes. International Journal of Molecular Sciences.
5.- González A, Osorio H, Romero S, Méndez P, Spúlveda M, Laporte D, Gutierrez-Cutiño M, Santander R, Castro-Nallar E, Moenne A. (2022). Transcriptomic analyses reveal increased expresión of dioxygenases, monooxygenases, and other metabolizing enzymes involved in anthracene degradation in the marine alga Ulva lactuca. Frontiers in Plant Science
4.- Méndez T, Fuentes A, Cofré D, Moenne A, Laporte D. (2023). Oligo-carrageenan kappa increases expresión of genes encoding proteins involved in photosynthesis, C, N and S assimilation, and growth in Arabidopsis thaliana International Journal of Molecular Sciences
3.- Osorio H, Laporte D, Romero S, Vidal C, Martínez F, Espinoza D, Romo X, Gallegos D, González A, Moenne A. (2024). Purification and characterization of ulvans from Chilean Ulva lactuca and assessment of the stimulation of growth induced by ulvans and oligo-ulvans in Arabidopsis thaliana Journal of Plant Growth Regulation
2.- Romero S, González A, Osorio H, Segura R, Moenne A. (2024). Copper is accumulated as copper sulfide particles, and not bound to glutathione, phytochelatins or metallthioneins, in the marine alga Ulva compressa (Cholorophyta). International Jourmal of Molecular Sciences
1.- Espinoza D, Laporte D, Martínes F, Sandino AM, Valdés N, Moenne A, Imarai M. (2024). Lambda carrageenan displays antiviral activity against infectious pancreatic necrosis virus (IPNV) by inhibiting viral replication and enhancing innate immunity in salmonid cells. International Journal of Biological Macromolecules