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Dr. Kevin Maisey
Biochemist and Comparative Immunologist, Associate Researcher at the Aquaculture Biotechnology Center of the University of Santiago de Chile. Biochemist from the Universidad de Santiago de Chile (2000) and Doctor of Biotechnology (2016), from the same University. His doctoral thesis focused on the study of the phenotypic and functional characteristics of immune cells in salmonids. Author and co-author of numerous articles on Immunology in humans, murine and fish. Since 2002 he has been a professor in the Department of Biology at the Universidad de Santiago de Chile where he develops his first studies in Reproductive Immunology. Since 2009 he has been dedicated to the area of fish immunology, particularly salmonids. Member of the Sociedad de Biología de Chile (SBCh), Asociación Chilena de Inmunología (ASOCHIN, Founding Partner), The International Society of Fish and Shellfish Immunology (ISFSI) and The International Society of Developmental and Comparative Immunology (ISDCI). He was Honorary Research Assistant at the Scottish Fish Immunology Research Center (SFIRC) at the University of Aberdeen, Scotland.
Currently, he leads the Comparative Immunology Laboratory integrating three research areas; Mechanisms of the lymphocyte response against bacterial pathogens using P. salmonis and A. salmonicida as a model, Molecular and cellular characterization of the rainbow trout TCR complex, and Development of molecular markers for the identification and functional characterization of subpopulations of immune cells in salmonids; all this, with the purpose of knowing in depth the molecular and cellular biology of the immune cells of salmonids and their interaction with pathogens that affect the Chilean aquaculture industry.
- Fondecyt Iniciación Project 11171057. Unraveling the early signaling pathways in T cell activation in salmonids: Characterization of T Cell Receptor CD3 Complex. (2017 – 2021).
- Strategic Investment Fund. Ministry of Economy. Program for Sanitary Management in Aquaculture FIE-2015-V014. Study of the immune status of Salmo salar under field conditions and its relationship with infection by Piscirickettsia salmonis and bases for the incorporation of immunomodulatory peptides in the diet as new drugs against the pathogen and piscirickettsiosis. No. 201708070149 (2017 – 2019).
- Mapping fish CD4 T cell subsets for vaccine improvement. RCUK-Conicyt MR/N02625X/1. (2016 - 2018).
- CORFO Project 13CTI-21527 (2014–2018). Technological Consortium for the Diagnosis and Prevention of Communicable Diseases in the Aquaculture Sector (USACH). Sub-Project KM-9: Evaluation of the immune response of salmonid T lymphocytes against pathogens.
- CORFO Project 13CTI-21527 (2014–2018). Technological Consortium for the Diagnosis and Prevention of Communicable Diseases in the Aquaculture Sector (USACH). Sub-Project KM-10: Development of new markers of B cells in salmonids – Tools to evaluate cell protection and the rational design of vaccines against intracellular pathogens.
-Flores-Kossack C, Montero R, Köllner B, Maisey K. 2020. Chilean aquaculture and the new challenges: Pathogens, immune response, vaccination and fish diversification. Fish Shellfish Immunol. doi: 10.1016/j.fsi.2019.12.093.
-Sequeida A, Castillo A, Cordero N, Wong V, Montero R, Vergara C, Valenzuela B, Vargas D, Valdés N, Morales J, Tello M, Sandino AM, Maisey K, Imarai M. 2020. The Atlantic salmon interleukin 4/13 receptor family: Structure, tissue distribution and modulation of gene expression. Fish Shellfish Immunol. doi: 10.1016/j.fsi.2019.11.030.
-Vallejos-Vidal E, Reyes-Cerpa S, Rivas-Pardo JA, Maisey K, Yáñez JM, Valenzuela H, Cea PA, Castro-Fernandez V, Tort L, Sandino AM, Imarai M, Reyes-López FE. 2020. Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar).
-Front Genet. Feb 27;10:1406. doi: 10.3389/fgene.2019.01406.
-Wang T, Hu Y, Wangkahart E, Liu F, Wang A, Zahran E, Maisey K, Liu M, Xu Q, Imarai M, Secombes CJ. 2018. Interleukin (IL)-2 is a key regulator of Th1 and Th2 cytokine expression in fish: functional characterisation of two divergent IL2 paralogues in salmonids. Front Immunol. 26; 9: 1683.
-Hu Y, Maisey K, Subramani PA, Liu F, Flores-Kossack C, Imarai M, Secombes CJ, Wang T. 2018. Characterisation of rainbow trout peripheral blood leucocytes prepared by hypotonic lysis of erythrocytes, and analysis of their phagocytic activity, proliferation and response to PAMPs and proinflammatory cytokines. Dev Comp Immunol. 88:104-113.
-Sequeida A, Maisey K, Imarai M. 2017. Interleukin 4/13 Receptors: an overview of genes, expression and functional role in teleost fish. Cytokine & Growth Factors Review. pii: S1359-6101(17)30140-5.
-Sanhueza L, Melo R, Montero R, Maisey K, Mendoza L, Wilkens M. 2017. Synergistic interactions between phenolic compounds identified in grape pomace extract with antibiotics of different classes against Staphylococcus aureus and Escherichia coli. PLoS One, 12(2): e0172273.
-Maisey K, Montero R, Christodoulides M. 2017. Vaccines for piscirickettsiosis (salmonid rickettsial septicaemia, SRS): the Chile perspective. Expert Rev Vaccines, 3: 215-228.