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Dr. Leonel Rojo

Charge: 
Biology Department. Toxicology and Metabolism Laboratory
E-mail: 
leonel.rojo@usach.cl

Biography: 

Dr. Leonel Rojo has a degree in Pharmacy and a  Pharmaceutical Chemist from the University of  Concepción, Doctorate in Pharmacology from the  University of Chile. He has Postdoctoral degree at  Rutgers University of the United States. He is also  a graduate of the Licensing Academy at the University of California, Davis. During his career he  has been a visiting scholar at the Kwantlen  Polytechnic University, Vancouver, Canada, Albert  Einstein College of Medicine, NY, USA, Brain-Mind  Project, Inc., USA, Encephalogistics, Inc, USA and  the National Institute of Engineering and  Technology (INETI) in Lisbon, Portugal. Dr. Rojo is  currently a Professor at the University of Santiago  de Chile. Co-founder and member of the Instituto  de Etnofarmacología in the Tarapacá Region and  independent consultant for companies in the  biomedical area, medical technologies, and  pharmacy. Member of the Steering Committee  FONDEF-Project N° ID19I10301 (2020-2023)

Research Area: 

Diagnostic technologies in Neurodegenerative  Diseases, New Natural Molecules in Diabetes, and  Insulin Resistance

Projects: 
  • 2020-2023 FONDEF N° ID19I10301 “Validación  técnica y comercial de la Tecnología Alz-tau®.  Comité Directivo (2020-2023)
  • 2015-2017, Evaluation of Anthocyanins from Maqui  Berry in the prevention of Clozapine-Induced  Hepatic Lipid Accumulation, Activation of SREBP1c  Target Genes and Obesity, FONDECYT INIC. N°  11140915
  • 2014-2017 Radiopharmaceuticals to visualize  neurofibrillary tangles in vivo CORFO-14IEAT 28666, Chile, Investigador
  • 2014-2015 Generación de Capacidades de  Transferencia Tecnológica en Corporación de  Desarrollo de la Universidad Arturo Prat" 14CHTT 34739, CORFO Chile 
Latest Publications: 
  • Barrera-Avalos C, Díaz X, Madrid B, Michelson SA, Robles-Planells C, Sánchez-Guerrero G, Ahumada V, Mella-Torres A, Rojo LE, Imarai M, Milla LA, Leiva-Salcedo E, Murgas P, Fernández R, Escobar A, Acuña-Castillo C. In Vivo Antitumor Effect against Murine Cells of CT26 Colon Cancer and EL4 Lymphoma by Autologous Whole Tumor Dead Cells. Biomed Res Int. 2021 Feb 3;2021:6626851. doi: 10.1155/2021/6626851. PMID: 33623783; PMCID: PMC7875630.
    IF: 2.583 Q2
  • Barrera-Avalos C, Mena J, López X, Cappelli C, Neira T, Imarai M, Fernández R, Robles-Planells C, Rojo LE, Milla LA, Leiva-Salcedo E, Escobar A, Acuña-Castillo C. Adenosine triphosphate, polymyxin B and B16 cell-derived immunization induce anticancer response. Immunotherapy. 2021 Mar;13(4):309-326. doi: 10.2217/imt-2020-0209. Epub 2021 Jan 5. PMID: 33397152.
    IF: 2.716 .Q2
  • Díaz-Castro, F., Monsalves-Álvarez, M., Rojo, L. E., Del Campo, A., & Troncoso, R. (2020). Mifepristone for Treatment of Metabolic Syndrome: Beyond Cushing's Syndrome. Frontiers in pharmacology, 11, 429. https://doi.org/10.3389/fphar.2020.00429. 
    IF 4.4. Q1
  • Robles-Planells C, Barrera-Avalos C, Rojo LE, Spencer E, Cortez-San Martin M, Matiacevich S, Pavez J, Milla LA, Navarro FD, Martínez BA, Bravo FJ, Mella A, Huidobro-Toro JP, Fernandez R, Escobar A, Acuña-Castillo C (2020), BioMed Research International "Chitosan-Based Delivery of Avian Reovirus Fusogenic Protein p10 Gene: In Vitro and In Vivo Studies towards a New Vaccine against Melanoma, Article ID 4045760, 11 pages,  https://doi.org/10.1155/2020/4045760, 
    IF: 2.27. Q1
  • Robles-Planells, C., Sánchez-Guerrero, G., Barrera-Avalos, C., Matiacevich, S., Rojo, L. E., Pavez, J., Salas-Huenuleo, E., Kogan, M. J., Escobar, A., Milla, L. A., Fernandez, R., Imarai, M., Spencer, E., Huidobro-Toro, J. P., & Acuña-Castillo, C. (2020). Chitosan-Based Nanoparticles for Intracellular Delivery of ISAV Fusion Protein cDNA into Melanoma Cells: A Path to Develop Oncolytic Anticancer Therapies. Mediators of inflammation, 2020, 8680692. https://doi.org/10.1155/2020/8680692, 
    IF: 3.758. Q1
  • Calfio C, Gonzalez A, Singh SK, Rojo LE, Maccioni RB. The Emerging Role of Nutraceuticals and Phytochemicals in the Prevention and Treatment of Alzheimer's Disease. (2020), J Alzheimers Dis. 2020;77(1):33-51. doi: 10.3233/JAD-200443. PMID: 32651325. 
    IF: 3.909. Q1
  • Robles-Planells, C., Michelson, S. A., Mena, J., Escrig, D., Rojas, J. L., Sanchez-Guerrero, G., Hernández, R., Barrera-Avalos, C., Rojo, L. E., Sauma, D., Kalergis, A. M., Imarai, M., Fernández, R., Robles, C. A., Leiva-Salcedo, E., Santander, R., Escobar, A., & Acuña-Castillo, C. (2019). Frontiers in pharmacology, Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma., 10, 1201. https://doi.org/10.3389/fphar.2019.01201 
    IF: 4.4. Q1
  • Del Campo A, Bustos C, Mascayano C, Acuña-Castillo C, Troncoso R and Rojo LE* (2018). Metabolic Syndrome and Antipsychotics: The Role of Mitochondrial Fission/Fusion Imbalance. Frontiers in Endocrinology, Frontiers Media SA, 9:144. doi: 10.3389/fendo.2018.00144, 
    IF: 3.675. Q1
  • Morales J, Barrera-Avalos C, Castro C, Castillo S, Barrientos C, Robles-Planells c, Lopez X, Torres E, Montoya M, Cortez-San Martín M, Riquelme D, Escobar A, Fernandez R, Imarai M, Sauma D, Rojo LE, Leiva-Salcedo E, Acuña-Castillo C (2017). Dead Tumor Cells expressing ISAV fusogenic protein favor antigen cross-priming in vitro. Frontiers in Immunology, Frontiers Media SA, 2017 Oct 9;8:1170. doi: 10.3389/fimmu.2017.01170., eCollection 2017. 
    IF: 6.429. Q1
  • Castillo RI, Rojo LE*, Henriquez-Henriquez M, Silva H, Maturana A, Villar MJ, Fuentes M, Gaspar PA* (2016). From Molecules to the Clinic: Linking Schizophrenia and Metabolic Syndrome through Sphingolipids Metabolism. Frontiers in Neuroscience, Frontiers Media SA, 10:488. eCollection 2016, 
    IF: 4.555. Q1
  • Rojo LE*, Gaspar PA, Silva H, Risco L, Arena P, Cubillos-Robles K, Jara B, (2015). Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology. Pharmacological Research, Academic Press LTD- Elsevier Science LTD, 101:74-85, 
    IF: 4.480. Q1
  • Graf, B. L., Rojas-Silva, P., Rojo, L. E., Delatorre-Herrera, J., Baldeón, M. E., and Raskin, I (2015). Innovations in Health Value and Functional Food Development of Quinoa (Chenopodium quinoa Willd.). Comprehensive Reviews in Food Science and Food Safety, Wiley, 14(4):431-445, 
    IF: 5.974. Q1
  • Graf BL, Rojo L.E., J. Delatorre-Herrera, A. Poulev, C. Del Pilar Calfio, and I. Raskin (2015). Phytoecdysteroids and flavonoid glycosides among Chilean and commercial sources of Chenopodium quinoa: variation and correlation to physicochemical characteristics. Journal of the Science of Food and Agriculture, Wiley, 96(2):633-43, 
    IF: 2.463. Q1