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Dr. Mario Tello
Efecto de los antibióticos sobre las OTU que responden a la filifolinona. La figura muestra los grupos de OTU que responden a filifolinona (102), cuya abundancia se ve afectada significativamente (p <0,05) por la preadministración de bacitracina y neomicina (69 OTU). La figura muestra (A) OTU pertenecientes a Kingdom Bacteria; (B) OTU pertenecientes al Reino Fungi; y (C) OTU pertenecientes al Reino Eukaryote. La abundancia de cada OTU se normalizó por la media más alta, ya sea de muestras de peces tratados con filifolinona o muestras de peces pretratados con antibióticos antes de la administración de filifolinona. La abundancia relativa se muestra en una escala de colores. La significación estadística se determinó mediante una prueba t con p <0,05. Las barras negras indican que no se detectaron OTU. (doi: 10.3390/microorganisms8091320.)
Biochemist from the Universidad de Chile (2000), Doctor of Biochemistry from the Universidad de Chile (2006), I did my undergraduate studies on the ligninolytic system of C. subvermispora and my doctoral studies on the export mechanism of microcin E492 under the direction of Dr. Rosalba Lagos (Faculty of Sciences, UCH)
My current research area is focused on understanding how the microbiota microorganisms can regulate the immune status of fish, with the aim of developing new treatments based on the use of probiotics. We also investigate the role of translational efficiency in the modulation of biological processes in viruses, bacteria, and fungi. Research in probiotics has made it possible to establish a company called Ictiobiotic SpA of which I am scientific director.
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The biphasic life style of Piscirickettsia salmonis: understanding its consequences for bacterial virulence.l 2021-2024l FONDECYT 1211893 l CoI
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Assessment of micropollutants removal and N2O production in a nitrifying sequencing moving bed biofilm reactor (SMBBR) with natural zeolite as biomass carrier l 2021-2024l FONDECYT 1210123 l CoI
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Desarrollo y validación de un probiótico que da inmunidad para prevenir del Síndrome rickettsial del Salmón.|2020-2021| Crea y valida I+D+i empresarial CORFO 19CVID-118939|IP
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Interplay between codon bias and tRNA levels modulates the translation of the genetic information.|2019-2022|FONDECYT1190552| CoI
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Development of recombinant strains of probiotics for in situ delivery of immunomodulatory peptides in Salmonids|2019-2020|ECOS-CONICYT| IP
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Ictiobiotics |2018-| “Platform to the in situ delivery of immunoestimulant peptides in Aquaculture”| Hatch-Blue| IP
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Validación y desarrollo de prototipos de probióticos para la salmonicultura| 2018-|VIU18E/P0073| Co-inv
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Development and application of technologies to improve animal health in Salmon production centers|2017-2018|CONICYT REDES150084|PI|$15.000.000. (En Curso) | IP
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Non-coding RNAs and translation efficiency coordinately contribute to the regulatory networks that control global gene expression in bacteria|2015-2019|Fondecyt 1150834|Co-researcher|$200.000.000
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Consorcio de Sanidad Acuícola|2013-2019|CORFO INNOVA 13CTI-21527|PI|$700.000.000
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Plataforma para la producción in situ de proteínas con actividad estimulante de la respuesta inmune en Salmónidos|2012-2015|FIA PYT20120056|PI|$150.000.000
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IMA genome - F14 : Draft genome sequences of Penicillium roqueforti, Fusarium sororula, Chrysoporthe puriensis, and Chalaropsis populi., van der Nest MA, Chávez R, De Vos L, Duong TA, Gil-Durán C, Ferreira MA, Lane FA, Levicán G, Santana QC, Steenkamp ET, Suzuki H, Tello M, Rakoma JR, Vaca I, Valdés N, Wilken PM, Wingfield MJ, Wingfield BD. IMA Fungus. 2021 Mar 5;12(1):5. doi:10.1186/s43008-021-00055-1. PMID: 33673862; PMCID: PMC7934431.
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Amplicon of 16S rRNA Gene Sequencing of Fertilized Volcanic Soils from Southern Chile. Vargas RA, Valdés N, Balic I, Contreras EI, Venegas C, Aranada CP, Tello M, Gonzalez AR. Microbiol Resour Announc. 2021 Mar 25;10(12):e00590-20. doi: 10.1128/MRA.00590-20. PMID: 33766903; PMCID: PMC7996462.
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Modification of Transfer RNA Levels Affects Cyclin Aggregation and the Correct Duplication of Yeast Cells. Arias L, Martínez F, González D, Flores-Ríos R, Katz A, Tello M, Moreira S, Orellana O. Front Microbiol. 2021 Jan 15;11:607693. doi: 10.3389/fmicb.2020.607693. PMID: 33519754; PMCID: PMC7843576.
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Metabolic Specialization and Codon Preference of Lignocellulolytic Genes in the White Rot Basidiomycete Ceriporiopsis subvermispora.Gonzalez A, Corsini G, Lobos S, Seelenfreund D, Tello M. Genes (Basel). 2020 Oct 20;11(10):1227. doi: 10.3390/genes11101227. PMID: 33092062; PMCID: PMC7588917.
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Microbiota Modulates the Immunomodulatory Effects of Filifolinone on Atlantic Salmon, Parra M., Espinoza D., Valdes D., Vargas R., Gonzalez A., Modak B., Tello M. Microorganisms 2020 Aug 30;8(9):E1320. doi: 10.3390/microorganisms8091320.
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New Copper(I) Complex with a Coumarin as Ligand with Antibacterial Activity against Flavobacterium psychrophilum. Aldabaldetrecu M., Parra M. Soto S., Arce P., Tello M., Guerrero J., Modak B. Molecules. 2020 Jul; 25(14): 3183. doi: 10.3390/molecules25143183
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Valdés N, Gonzalez A, Garcia V, Tello M. Analysis of the microbiome of rainbow trout (Oncorhynchus mykiss) exposed to the pathogen Flavobacterium psychrophilum strain 10094. Microbiol Resour Announc. 2020 Mar; 9(12): e01562-19. doi: 10.1128/MRA.01562-19
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Sequeida A, Castillo A, Cordero N, Wong V, Montero R, Vergara C, Valenzuela B, Vargas D, Valdés N, Morales J, Tello M, Sandino AM, Maisey K, Imarai M. The Atlantic salmon interleukin 4/13 receptor family: Structure, tissue distribution and modulation of gene expression. Fish Shellfish Immunol. 2019 Nov 15. pii: S1050-4648(19)31073-3. doi: 10.1016/j.fsi.2019.11.030.
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Tello M., Avalos F., Orellana 0. Codon usage and modular interactions between messenger RNA coding regions and small RNAs in Escherichia coli. BMC Genomics. 2018 Sep 6;19(1):657. doi: 10.1186/s12864-018-5038-6.
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Cartagena J, Tambley C, Sandino AM, Spencer E, Tello M. Detection of piscine orthoreovirus in farmed rainbow trout from Chile. Aquaculture. 2018: 493, 10.1016/j.aquaculture.2018.04.044 ISI 2,570
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Castillo A, Tello M, Ringwald K, Acuña LG, Quatrini R, Orellana O. A DNA segment encoding the anticodon stem/loop of tRNA determines the specific recombination of integrative-conjugative elements in Acidithiobacillus species. RNA Biol. 2018 15(4-5):p 492- doi: 10.1080/15476286.2017.1408765 ISI 3,9
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Alamos P, Tello M, Bustamante P, Gutiérrez F, Shmaryahu A, Maldonado J, et al. Functionality of tRNAs encoded in a mobile genetic element from an acidophilic bacterium. RNA Biol. 2018; 15(4-5):518-527 doi:10.1080/15476286.2017.1349049
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Caamaño E, Loperena L, Hinzpeter I, Pradel P, Gordillo F, Corsini G, et al. Isolation and molecular characterization of Thraustochytrium strain isolated from Antarctic Peninsula and its biotechnological potential in the production of fatty acids. Brazilian J Microbiol. 2017; doi:10.1016/j.bjm.2017.01.011
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Rojas-Aedo JF, Gil-Durán C, Del-Cid A, Valdés N, Álamos P, Vaca I, et al. The Biosynthetic Gene Cluster for Andrastin A in Penicillium roqueforti. Front Microbiol. 2017;8: 813. doi:10.3389/fmicb.2017.00813 Vargas-Straube MJ, Cámara B, Tello M, Montero-Silva F, Cárdenas F, Seeger M. Genetic and Functional Analysis of the Biosynthesis of a Non Ribosomal Peptide Siderophore in Burkholderia xenovorans LB400. Janssen PJ, editor. PLoS One. 2016;11: e0151273. doi:10.1371/journal.pone.0151273