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Dr. Brenda Modak

Charge: 
Environmental Sciences Department. Natural Products Chemistry Laboratory
E-mail: 
brenda.modak@usach.cl

Biography: 

Doctor of Chemistry, Universidad de Santiago de  Chile, 1998. Full-time Academic, Department of  Environmental Sciences, Faculty of Chemistry and  Biology, Universidad de Santiago de Chile.

Research Area: 

Chemistry of Natural Products  and their applications as immunostimulants,  antivirals, antibacterials and antioxidants.

Projects: 

  • Researcher in charge (2018-2022) Fondecyt Project N°1180265 “New tools for the control of  pathogens in the salmon industry: copper  complex formed with compounds of natural origin  with potential immunostimulant and/or  

    antimicrobial activity”.

  • Researcher in charge (2011-2013) Proyecto  Fondecyt Project Nº 1110295 “Obtaining natural  products with immunostimulatory and/or adjuvant  activity in salmonid cells for veterinary  

    applications: optimization of commercial  vaccines”.

  • Researcher in charge (2014-2018) Fondecyt  Project Nº1140261 “Evaluation of new natural  products with potential antibacterial activity  against Piscirickettsia salmonis: a health challenge  for the salmon industry”

 

Latest Publications: 

-Valenzuela.B, Imarai.M, Catalán.R, Parra.M, Soto.S, Sandino.A, Torres.R, Modak.B*. 

“Evaluation of the bactericidal activity of secondary metabolites isolated from Heliotropium genus against Piscirickettsia salmonis”. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 14, 131-140, 2015.

-Valenzuela.B; Obreque.J; Soto.S; Maisey.K; Imarai.M, Modak.B*. “Key cytokines of adaptive immunity are differentially induced in rainbow trout kidney by a group of structurally related geranyl aromatic derivatives”. Fish & Shellfish Immunology 49, 45-53, 2016.

-Fazel Nabavi.S*, Uriarte.E, Rastrelli.L, Modak.B, Sobarzo-Sanchez.E. Aporphines and Parkinson’s Disease: Medical Tools for the Future. Current Topics in Medicinal Chemistry 16, 1906-1909, 2016.

-Barriga-González.G*, Chamorro.E, Salinas.M, Modak.B, Olea-Azar.C.  Evaluation of the antioxidant activity of the flavonoids isolated from Heliotropium sinuatum resin using orac fl, dpph and esr methodologies. J. Chil. Chem. Soc., 61,2852-2856, 2016.

-Parra.M, Valenzuela.B, Soto.S, Modak.B*. “Antibacterial activity of cuticular components from Heliotropium species, against Staphylococcus aureus and Salmonella tiphymurium”. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 15, 422 – 428, 2016. 

-Espinoza. D, Valenzuela. B, Modak.B*. Immunostimulatory activity in mammalian cells of 3,5-dihydroxy-7-methoxyflavanone ((-)-alpinone) isolated from Heliotropium huascoense resinous exudates. BLACPMA, 16, 577-584, 2017

-Parra.M, Valenzuela.B, Imarai.M, Modak.B*. Obtainment and evaluation of adjuvant effect of the aromatic geranyl derivative Filifolinone in bacterin of Piscirickettsia salmonis. Journal of Fish Diseases. 41, 157-159, 2018.

-Valenzuela B, Rodríguez F, Modak B*, Imarai M*. Alpinone exhibited immunomodulatory and antiviral activities in Atlantic salmon. Fish and Shellfish Immunology 74, 76–83, 2018.

-Valdés C, Valenzuela B, Modak B*. Evaluation in vitro of proliferative activity of epithelial cells by flavonoid 3-O-methylgalangine and terpenenic derivative Filifolinone. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 17, 575-582, 2018.

-Valenzuela B*, Espinoza D, Camus C, Epuyao N, Modak B. Alpinone exhibit immunostimulant effects in Atlantic salmon kidney. Fish & Shellfish Immunology 91, 394, 2019.

-Modak B*, Valenzuela B, Soto F, Parra M, Vergara C, Imarai M. Filifolinone, a natural compound with adjuvant effect for optimization of a comercial vaccine for IPNV. Fish & Shellfish Immunology 91, 395, 2019.

-Aldabaldetrecu, M; Parra, M; Soto, S; Arce, P; Tello, M; Guerrero, J*; Modak, B*. 2020. New Copper(I) Complex with a Coumarin as Ligand with Antibacterial Activity against Flavobacterium psychrophilum. Molecules, 25,3183-3193 

-Parra, M.; Espinoza, D.; Valdes, N.; Vargas, R.; Gonzalez, A.; Modak, B*.; Tello, M*. 2020. Microbiota Modulates the Immunomodulatory Effects of Filifolinone on Atlantic Salmon. Microorganisms, 8, 1320-1341

-Vilchez,L*; Becerra.M; Modak .B. 2020. Diastereoselective Synthesis of Spirodihydrobenzofuran Analogues of the Natural Product Filifolinol. ChemistrySelect. (aceptada) DOI: 10.1002/slct.202003580