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Dra. Leonora Mendoza
En Chile la producción de frutas como las uvas, cerezas, entre otras es afectada por diferentes patógenos, entre ellos el hongo Botrytis cinerea. Este hongo ha sido clasificado como el segundo hongo fitopatógeno más importante a nivel mundial, produciendo pérdidas de hasta un 30% en la producción de frutas. El control de este hongo se hace principalmente con fungicidas de origen sintético. La línea de investigación del laboratorio de Micología es la búsqueda y caracterización de extractos o compuestos puros naturales con actividad antifúngica contra B. cinerea. Los extractos o compuestos puros son obtenidos de hongos endófitos, aislados de plantas que crecen en el Cajón del Maipo. Algunos de los hongos aislados, identificados como, Aureobasidium sp, Epicoccum sp, Naganishia sp., entre otros inhiben el crecimiento micelial de B. cinerea por el mecanismo de antibiosis, a través de la producción de compuestos volátiles y no volátiles. Se identificó los compuestos volátiles producidos por Naganishia sp y se determinó que estos compuestos producen estrés oxidativo, daño en la pared celular y en la membrama plasmática de B. cinerea.
Professor of Chemistry and Biology, University of Santiago de Chile. Doctorate in Chemistry, University of Santiago de Chile, 1986, Chile.
Organic Chemistry; Biology.
- Title: 2023-2026. FONDECYT 1230464. Award year: 2023. Execution period: 4 years. Principal Reseracher
- Title: Reuse of waste from the food industry. Obtaining extracts, chemical analysis, and determining antifungal activity against the phytopathogenic fungus Botrytis cinerea. Determination of the possible mode of action. DICYT USACH. Award year: 2021. Execution period: 3 years. Principal Researcher
- Title: Identification of the molecular mechanism of action of extracts or pure compounds against Botrytis cinerea. DICYT USACH. Award year: 2015. Execution period: 2 years. Co-researcher
- Synergistic effect of extracts or pure compounds obtained from grape pomace with synthetic fungicides used against the fungus Botrytis cinerea. Reduction of application rates and determination of the site of action. DICYT USACH. Award year: 2017. Execution period: 2 years. Principal Researcher.
- Title: Design of sensing electrodes with renewable surface for detecting analyses of interest in the food industry. Determination of the role of each element of the composite electrode in the global response. FONDECYT 1160324. Year of award: 2016. Execution period: 3 years. Co-Researcher.
- Title: Improvement of Antifungal and Antibacterial Activities from Extracts or Phenolic Compounds Obtained from Winery By-Products. FONDECYT 1130389. Award year: 2013. Execution period: 3 years. Principal Researcher
- Title: Development of a fungicide produced from wine industry waste against the phytopathogenic fungus Botrytis cinerea. FONDEF IDEA CA12i10054. Award year: 2013. Execution period: 2014. Alternate director
1 R. Parada,L. Mendoza,M. Cotoras, C. Ortiz 2022 Endophytic fungi isolated from plants present in a mine tailing facility show a differential growth response to lead. Letters in Applied Microbiology.
2 Rodrigo A. Contreras, Marisol Pizarro, Nicolás Peña-Heyboer, Leonora Mendoza, Camila Sandoval, Rodrigo Muñoz-González & Gustavo E. Zúñiga 2022 Antifungal activity of extracts from the Antarctic plant Colobanthus quitensis Kunth. (Bartl) cultured in vitro against Botrytis cinerea Pers Archives of Phytopathology and Plant Protection.
3 Paulo Castro, Rodolfo Parada , Carlos Corrial, Leonora Mendoza * and Milena Cotoras * 2022 2022 Endophytic Fungi Isolated from Baccharis linearis and Echinopsis chiloensis with Antifungal Activity against Botrytis cinerea. J of Fungi.
4 Ricardo Melo 1 , Verónica Armstrong 2 , Freddy Navarro 3 , Paulo Castro 3 , Leonora Mendoza 3,* and Milena Cotoras 3* 2021 Characterization of the Fungitoxic Activity on Botrytis cinerea of N-phenyl-driman-9-carboxamides. J of Fungi.
5 Araceli Vidal, Rodolfo Parada, Leonora Mendoza, Milena Cotoras 2020 Endophytic fungi isolated from plants growing in central Andean Precordillera of Chile with antifungal activity against Botrytis cinerea. Journal of fungi.
6 Javier Espinoza1,2 *, Alejandro Urzúa3 *, Loreto Sanhueza4 *, Mariana Walter5 , Paola Fincheira2,6, Patricia Muñoz4 , Leonora Mendoza7 and Marcela Wilkens8 2019 Essential Oil, Extracts, and Sesquiterpenes Obtained from the Heartwood of Pilgerodendron uviferum Act as Potential Inhibitors of the Staphylococcus aureus NorA Multidrug Efflux Pump Frontiers in microbiology.
7 Paulo Castro, Leonora Mendoza, Claudio Vásquez, Paz Cornejo, Freddy Navarro, Milena Cotoras 2019 Antifungal activity against Botrytis cinerea of 2,6-dimethoxy-4 (phenylimino)benzenone derivatives Molecules.
8 Leonora Mendoza , Marcela Vivanco, Ricardo Melo, Paulo Castro, Ramiro Araya-Maturana, Milena Cotoras 2019 Detoxification mechanisms of 8,8-dimethyl-3-[(r-phenyl)amino]-1,4,5(8h)- naphtalentrione derivatives by Botrytis cinérea Molecules .
9 Melo, Ricardo; Sanhueza, Loreto; Mendoza, Leonora; Cotoras, Milena 2018 Characterization of the fungitoxic activity on Botrytis cinerea of the aristolochic acids I and II. Letters in Applied Microbiology.
10 Claudia Torrent, Carlos Gil-Durán, Juan F. Rojas-Aedo, Exequiel Medina, Inmaculada Vaca, Paulo Castro, Ramón O. García-Rico, Milena Cotoras, Leonora Mendoza, Gloria Levicán And Renato Chávez 2017 Role of sfk1 Gene in the Filamentous Fungus Penicillium roquefortin. Frontiers in microbiology.
11 Morales, J., Mendoza, L. And Cotoras, M. 2017 Alteration of oxidative phosphorylation as a possible mechanism of the antifungal action of p-coumaric acid against Botrytis cinerea. Journal of applied microbiology .
12 Javier Echeverría, Julia Opazo, Leonora Mendoza, Alejandro Urzúa, Marcela Wilkens* 2017 Structure-activity and lipophilicity relationships of selected antibacterial natural flavones and flavanones of chilean flora Molecules.
13 Silva W; Romero, J; Morales, E; Melo, R; Mendoza Cotoras, M.* 2017 Red wine extract obtained by membrane-based supercritical fluid extraction: preliminary characterization of chemical properties. Brazilian journal of chemical engineering.
14 Marcela Wilkens, Loreto Sanhueza, Ruht Montero, Kevin, Masey, Ricardo Melo, Leonora Mendoza* 2017 Synergistic interactions between phenolic compounds identified in grape pomace extract with antibiotics of different classes against staphylococcus aureus and escherichia coli.
15 Mendoza, L.; Vásquez, J.; Campos, A.; Melo, R. Cotoras,M.* 2016 Lacasse catalyzed-synthesis of 4,4 '-biphenyldiamine from p-chloroaniline. Evaluation of antifungal and antioxidant activities. JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
16 Mendoza,L; Castro,P; Melo, R; Campo,A; Zuñiga, G; Guerrero, J; Cotoras, M.* 2016 Improvement of the antifungal activity against botrytis cinerea of syringic acid, a phenolic acid from grape pomace. Journal Chilean Chemical Society.
17 Mendoza,L; Sepúlveda,C; Melo,R; Cotoras,M* 2015 CHARACTERIZATION OF THE ANTIFUNGAL ACTIVITY AGAINST BOTRYTIS CINEREA OF SCLAREOL AND 13-EPI-SCLAREOL, TWO LABDANE-TYPE DITERPENOIDS. Journal Chilean Chemical Society.
18 Mendoza, L., Ribera, A., Saavedra, A., Silva, E., Araya-Maturana, R., Cotoras, M.* 2015 Action mechanism for 3 beta-hydroxykaurenoic acid and 4,4-dimethylanthracene-1,9,10(4H)-trione on Botrytis cinerea Mycologia.
19 Cotoras,M.; Vivanco, H.; Melo, R.; Aguirre, M.; Silva, E.; Mendoza,L*. 2014 In Vitro and in Vivo Evaluation of the Antioxidant and Prooxidant Activity of Phenolic Compounds Obtained from Grape (Vitis vinifera) Pomace Molecules.
20 Loreto Sanhueza, Mario Tello, Marcela Vivanco, Leonora Mendoza, Marcela Wilkens*. 2014 Relation between Antibacterial Activity against Food Transmitted Pathogens and Total Phenolic Compounds in Grape Pomace Extracts from Cabernet Sauvignon and Syrah Varieties Advances in microbiology
21 Leonora Mendoza*, Milena Cotoras, Marcela Vivanco, Betty Matsuhiro, Simonet Torres, María Aguirre. 2013 EVALUATION OF ANTIFUNGAL PROPERTIES AGAINST THE PHYTOPATHOGENIC FUNGUS BOTRYTIS CINEREA OF ANTHOCYANIN RICH-EXTRACTS OBTAINED FROM GRAPE POMACES. Journal Chilean Chemical Society
22 Leonora Mendoza, Karen Yañez, Marcela Vivanco, Ricardo Melo, Milena Cotoras*. 2013 Characterization of extracts from winery by-products with antifungal activity against Botrytis cinerea. INDUSTRIAL CROPS AND PRODUCTS
23 Milena Cotoras, Paulo Castro, Herman Vivanco, Ricardo Melo, Leonora Mendoza* 2013 Farnesol induces apoptosis-like phenotype in the phytopathogenic fungus Botrytis cinerea Mycologia.
24 Paulina Dreyse, Diego Quezada, Jessica Honores, María Jesús Aguirre, Leonora Mendoza, Betty Masuhiro, Diego Villagra 2012 Determination of S(IV) oxoanions at poly-[Ru(5-NO2-phen)2Cl] tetrapyridylporphyrin glassy carbon modified electrode Electroanalysis.